Osmosis Jones

1h 35m · 2001 · Directed by Bobby Farrelly, Peter Farrelly · 3.0 / 5 on Letterboxd

Osmosis Jones (2001) runs 1h 35m, directed by Bobby Farrelly, Peter Farrelly. It is one of 3,647 films in the 100 Minute Movies catalog — every one rated 3.0 or higher by Letterboxd members and short enough to finish in an evening.

A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

Genres: Action, Family, Comedy, Animation, Adventure

No US streaming listed when we last checked (9 July 2026). Availability changes often.